ROLE OF ATG POLYCLONAL ANTIBODIES(14)

Regulatory T cells (Treg) play important roles in suppress immune responses and maintain tolerance. Rabbit antithymocyte globulin (rATG) and horse ATG (hATG) are broadly used in the treatment of immune-mediated syndromes, other than their effects on Treg are indefinite. We show here that In vitro culture of standard human peripheral blood mononuclear cells (PBMCs) through a low-dose rATG resulted in marked expansion of practical Treg by convert CD4+CD25- T cells to CD4+CD25+ T cells.

Leukocyte sticking to the endothelium, transendothelial movement, collaboration between immunocompetent cells, and cytotoxicity are acting as a central role among adhesion molecules. In a multicenter randomized open test, we compare a monoclonal antibody directed against the a chain of LFA-1 (Odulimomab; IMTIX/Pasteur Merieux Serums et Vaccins) among rabbit antithymocyte globulin(rATG; IMTIX/Pasteur Merieux Serums et Vaccins), as part of a quadruple sequential procedure in 101 patients getting a first kidney transplant.

Alloantibody – mediated acute refusal is a major cause of renal allograft thrashing despite insistent therapy. Patients with humeral rejection can be identified with high sensitivity and specificity by the existence of per tubular vessel C4d stain on renal biopsy and donor-specific anti-human leukocyte antigen antibodies. Regular therapy for acute humoral rejection (AHR) has been removal of donor-specific antibodies by plasmapheresis (PPH) in combination with intravenous immunoglobulin analysis.